2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000
Flentie F, Kocher B, Gammon ST, Novack DV, McKinney JS, Piwnica-Worms D. A Bioluminescent Transposon Reporter-Trap Identifies Tumor-Specific Microenvironment-Induced Promoters in Salmonella for Conditional Bacterial-Based Tumor Therapy. Cancer Discovery. 2012, In press. |
PubMed Link |
Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Leitch M, Hunt K, Olson J, Tao Y, Maher CA, Fulton LL, Fulton RS, Harrison M, Oberkfell B, Du F, Demeter R, Vickery TL, Elhammali A, Piwnica-Worms H, McDonald S, Watson M, Dooling DJ, Ota D, Chang LW, Bose R, Ley TJ, Piwnica-Worms D, Stuart JM, Wilson RK, Mardis ER. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature. 2012 Jun 10;486(7403):353-60. |
PubMed Link |
Macdonald-Obermann JL, Piwnica-Worms D, Pike LJ. Mechanics of EGF Receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging. Proc Natl Acad Sci USA. 2012 Jan 3;109(1):137-42. |
PubMed Link |
Ilagan MX, Lim S, Fulbright M, Piwnica-Worms D, Kopan R. Real-time imaging of notch activation with a luciferase complementation-based reporter. Sci Signal. 2011; 4(181): rs7. |
PubMed Link |
Liu Z, Turkoz A, Jackson EN, Corbo JC, Engelbach JA, Garbow JR, Piwnica-Worms DR, Kopan R. Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest. 2011; 121(2): 800-8. |
PubMed Link |
Villalobos V, Naik S, Bruinsma M, Dothager RS, Pan MH, Samrakandi M, Moss B, Elhammali A, Piwnica-Worms D. Dual-color click beetle luciferase heteroprotein fragment complementation assays. Chem Biol. 2010; 17(9): 1018-29. |
PubMed Link |
Liu CC, Prior J, Piwnica-Worms D, Bu G. LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Proc Natl Acad Sci USA. 2010; 107(11): 5136-41. |
PubMed Link |
Barnett EM, Zhang X, Maxwell D, Chang Q, Piwnica-Worms D. Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model. Proc Natl Acad Sci USA. 2009; 106(23): 9391-6. |
PubMed Link |
Gross S, Gammon ST, Moss BL, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D. Bioluminescence imaging of myeloperoxidase actvity in vivo. Nat Med. 2009 15(4): 455-61. |
PubMed Link |
Pichler A, Prior JL, Luker GD, Piwnica-Worms D. Generation of a highly-inducible Gal4→Fluc universal reporter mouse for in vivo bioluminescence imaging. Proc Natl Acad Sci USA. 2008; 105(41): 15932-7. |
PubMed Link |
Kocher B, Piwnica-Worms D. Illuminating Cancer Systems with Genetically Engineered Mouse Models and Coupled Luciferase Reporters In Vivo. Cancer Discov. 2013; in press. |
Yang C, Davis JL, Zeng R, Vora P, Su X, Collins LI, Vangveravong S, Mach RH, Piwnica-Worms D, Weilbaecher KN, Faccio R, Novack DV. Antagonism of Inhibitor of Apoptosis Proteins Increases Bone Metastasis via Unexpected Osteoclast Activation. Cancer Discov. 2013 Feb;3(2):212-23. |
Hurchla MA, Garcia-Gomez A, Hornick MC, Ocio EM, Li A, Blanco JF, Collins L, Kirk CJ, Piwnica-Worms D, Vij R, Tomasson MH, Pandiella A, Miguel JS, Garayoa M, Weilbaecher KN. The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects. Leukemia. 2013 Feb;27(2):430-40. |
Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, Hewitt SM, Mallya Udupi G, Gallagher WM, Wegner C, West BL, Wang-Gillam A, Goedegebuure P, Linehan DC, Denardo DG. Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression and improves chemotherapeutic response. Cancer Res. 2013 Feb 1;73(3):1128-1141. |
Choi J, Ziga ED, Ritchey J, Collins L, Prior JL, Cooper ML, Piwnica-Worms D, Dipersio JF. IFNγR signaling mediates alloreactive T cell trafficking and GvHD. Blood. 2012 Nov 8;120(19):4093-103. |
Blumer KJ, Weilbaecher K, Piwnica-Worms D. Bioluminescence Imaging of Prenylation Inhibition-Response. Clin Cancer Res. 2012 Nov 1;18(21):6078. |
Su X, Floyd DH, Hughes A, Xiang J, Schneider JG, Uluckan O, Heller E, Deng H, Zou W, Craft CS, Wu K, Hirbe AC, Grabowska D, Eagleton MC, Townsley S, Collins L, Piwnica-Worms D, Steinberg TH, Novack DV, Conley PB, Hurchla MA, Rogers M, Weilbaecher KN. The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling. J Clin Invest. 2012 Oct 1;122(10):3579-92. |
Johnson JR, Kocher B, Barnett EM, Marasa J, Piwnica-Worms D. Caspase-Activated Cell-Penetrating Peptides Reveal Temporal Coupling Between Endosomal Release and Apoptosis in an RGC-5 Cell Model. Bioconjug Chem. 2012 Sep 19;23(9):1783-93. |
Li Y, Macdonald-Obermann J, Westfall C, Piwnica-Worms D, Pike LJ. Quantitation of the effect of ErbB2 on EGF receptor binding and dimerization. J Biol Chem. 2012 Sep 7;287(37):31116-25. |
Moss BL, Elhammali A, Fowlkes T, Gross S, Vinjamoori A, Contag CH, Piwnica-Worms D. Interrogation of IκBα:NF-κB (inhibitor of nuclear factor κBα:Nuclear factor κB) negative feedback loop dynamics: From single cells to live animals in vivo. J Biol Chem. 2012 Sep 7;287(37):31359-70. |
Chinault SL, Prior J, Kaltenbronn KM, Penly A, Weilbaecher KN, Piwnica-Worms D, Blumer KJ. Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter. Clin Cancer Res. 2012 Aug 1;18(15):4136-44. |
Sundaram GS, Harpstrite SE, Kao JL, Collins SD, Sharma V. A New Nucleoside Analogue with Potent Activity against Mutant sr39 Herpes Simplex Virus-1 (HSV-1) Thymidine Kinase (TK). Org Lett. 2012;14(14): 3568-3571. |
Flentie K, Kocher B, Gammon ST, Novack DV, McKinney JS, Piwnica-Worms D. A Bioluminescent Transposon Reporter-Trap Identifies Tumor-Specific Microenvironment-Induced Promoters in Salmonella for Conditional Bacterial-Based Tumor Therapy. Cancer Discovery. 2012 Jul;2(7):624-37. |
Ellis MJ, Ding L, Shen D, Luo J, Suman VJ, Wallis JW, Van Tine BA, Hoog J, Goiffon RJ, Goldstein TC, Ng S, Lin L, Crowder R, Snider J, Ballman K, Weber J, Chen K, Koboldt DC, Kandoth C, Schierding WS, McMichael JF, Miller CA, Lu C, Harris CC, McLellan MD, Wendl MC, DeSchryver K, Allred DC, Esserman L, Unzeitig G, Margenthaler J, Babiera GV, Marcom PK, Guenther JM, Leitch M, Hunt K, Olson J, Tao Y, Maher CA, Fulton LL, Fulton RS, Harrison M, Oberkfell B, Du F, Demeter R, Vickery TL, Elhammali A, Piwnica-Worms H, McDonald S, Watson M, Dooling DJ, Ota D, Chang LW, Bose R, Ley TJ, Piwnica-Worms D, Stuart JM, Wilson RK, Mardis ER. Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature. 2012 Jun 10;486(7403):353-60. |
Adair-Kirk TL, Meyer MJ, Vikas HG, Tichelaar JW, Jackson EN, Piwnica-Worms DR, Senior RM. Lung laminin-332 deficiency enhances engraftment of tumor cells into the lung but retards tumor cell growth. Proc Am Thorac Soc. 2012 May;9(2):83. |
Pazolli E, Alspach E, Milczarek A, Prior J, Piwnica-Worms D, Stewart SA. Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res. 2012 May 1;72(9):2251-61. |
Xu Z, Joshi N, Agarwal A, Dahiya S, Bittner P, Smith E, Taylor S, Piwnica-Worms D, Weber J, Leonard JR. Knocking down nucleolin expression in gliomas inhibits tumor growth and induces cell cycle arrest. J Neurooncol. 2012 May;108(1):59-67. |
Rao S, Sengupta R, Choe EJ, Woerner BM, Jackson E, Sun T, Leonard J, Piwnica-Worms D, Rubin JB. CXCL12 Mediates Trophic Interactions between Endothelial and Tumor Cells in Glioblastoma. PLoS One. 2012;7(3):e33005. |
Piwnica-Worms D. On in vivo imaging in cancer. Cold Spring Harb Perspect Biol. 2012 Mar 1;4(3). |
Heller E, Hurchla MA, Xiang J, Chen S, Schneider J, Joeng KS, Vidal M, Goldberg L, Deng H, Hornick MC, Prior J, Piwnica-Worms DR, Long F, Cagan R, Weilbaecher K. Hedgehog signaling inhibition blocks growth of resistant tumors through effects on tumor microenvironment. Cancer Res. 2012 Feb 15;72(4):897-907. |
Blasberg R, Piwnica-Worms D. Imaging: strategies, controversies, and opportunities. Clin Cancer Res. 2012 Feb 1;18(3):631-7. |
Chen DY, Lee Y, Van Tine BA, Searleman AC, Westergard TD, Liu H, Tu HC, Takeda S, Dong Y, Piwnica-Worms DR, Oh KJ, Korsmeyer SJ, Hermone A, Gussio R, Shoemaker RH, Cheng EH, Hsieh JJ. A Pharmacological Inhibitor of the Protease Taspase1 Effectively Inhibits Breast and Brain Tumor Growth. Cancer Res. 2012 Feb 1;72(3):736-746. |
Fuentealba RA, Marasa J, Diamond MI, Piwnica-Worms D, Weihl CC. An aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors. Hum Mol Genet. 2012 Feb 1;21(3):664-80. |
Woerner BM, Luo J, Brown KR, Jackson E, Dahiya SM, Mischel PS, Benovic J, Piwnica-Worms D, Rubin JB. Suppression of G protein-coupled Receptor Kinase 3 expression is a feature of Classical GBM that is required for maximal growth. Mol Cancer Res. 2012 Jan;10(1):156-66. |
Macdonald-Obermann JL, Piwnica-Worms D, Pike LJ. Mechanics of EGF Receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging. Proc Natl Acad Sci USA. 2012 Jan 3;109(1):137-42. |
Pasieka TJ, Collins L, O'Connor MA, Chen Y, Parker ZM, Berwin BL, Piwnica-Worms DR, Leib DA. Bioluminescent Imaging Reveals Divergent Viral Pathogenesis in Two Strains of Stat1-Deficient Mice, and in αβγ Interferon Receptor-Deficient Mice. PLoS One 2011; 6(9): e24018. |
Dothager RS, Piwnica-Worms D. Nano in Cancer: Linking Chemistry, Biology, and Clinical Applications In Vivo. Cancer Res 2011; 71(17): 5611-5. |
Tinkum KL, Marpegan L, White LS, Sun J, Herzog ED, Piwnica-Worms D, Piwnica-Worms H. Bioluminescence Imaging Captures the Expression and Dynamics of Endogenous p21 Promoter Activity in Living Mice and Intact Cells. Mol Cell Biol 2011; 31(18): 3759-72. |
Ilagan MX, Lim S, Fulbright M, Piwnica-Worms D, Kopan R. Real-time imaging of notch activation with a luciferase complementation-based reporter. Sci Signal 2011; 4(181): rs7.
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Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes Dev 2011; 25(13): 1426-38. |
Smith BA, Daschbach MM, Gammon ST, Xiao S, Chapman SE, Hudson C, Suckow M, Piwnica-Worms D, Gokel GW, Leevy WM. In vivo cell death mediated by synthetic ion channels. Chem Commun (Camb) 2011; 47(28): 7977-9. |
Smith BA, Gammon ST, Xiao S, Wang W, Chapman S, McDermott R, Suckow MA, Johnson JR, Piwnica-Worms D, Gokel GW, Smith BD, Leevy WM. In Vivo Optical Imaging of Acute Cell Death Using a Near-Infrared Fluorescent Zinc-Dipicolylamine Probe. Mol Pharm 2011; 8(2): 583-90. |
Liu Z, Turkoz A, Jackson EN, Corbo JC, Engelbach JA, Garbow JR, Piwnica-Worms DR, Kopan R. Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice. J Clin Invest 2011; 121(2): 800-8. |
Olanich ME, Moss BL, Piwnica-Worms D, Townsend RR, Weber JD. Identification of FUSE-binding protein 1 as a regulatory mRNA-binding protein that represses nucleophosmin translation. Oncogene 2011; 30(1): 77-86. |
Zhou P, Gross S, Liu JH, Yu BY, Feng LL, Nolta J, Sharma V, Piwnica-Worms D, Qiu SX. Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-{kappa}B and MAPK signaling pathways. FASEB J 2010; 24(12): 4722-32. |
Rauch DA, Hurchla MA, Harding JC, Deng H, Shea LK, Eagleton MC, Niewiesk S, Lairmore MD, Piwnica-Worms D, Rosol TJ, Weber JD, Ratner L, Weilbaecher KN. The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice. PLoS One 2010; 5(12): e15755. |
Lennerz JK, Hurov JB, White LS, Lewandowski KT, Prior JL, Planer GJ, Gereau RW 4th, Piwnica-Worms D, Schmidt RE, Piwnica-Worms H. Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis and defective gluconeogenesis. Mol Cell Biol 2010; 30(21): 5043-56. |
Dothager RS, Goiffon RJ, Jackson E, Harpstrite S, Piwnica-Worms D. Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems. PLoS One 2010; 5(10): e13300. |
Pan MH, Lin J, Prior JL, Piwnica-Worms D. Monitoring Molecular-Specific Pharmacodynamics of Rapamycin In vivo with Inducible Gal4->Fluc Transgenic Reporter Mice. Mol Cancer Ther 2010; 9(10): 2752-60. |
Villalobos V, Naik S, Bruinsma M, Dothager RS, Pan MH, Samrakandi M, Moss B, Elhammali A, Piwnica-Worms D. Dual-color click beetle luciferase heteroprotein fragment complementation assays. Chem Biol 2010; 17(9): 1018-29. |
Sivapackiam J, Harpstrite SE, Prior JL, Piwnica-Worms D, Sharma V. SPECT Metalloprobes for Monitoring MDR1 P-Glycoprotein-Mediated Transport at the Blood-Brain Barrier (BBB). In: Technetium and Other Radiometals in Chemistry and Medicine. Mazzi U, Eckelman, WC, Volkert WA (Ed.), SGE Padova, 2010; 559-563 |
Piwnica-Worms D, Sharma V. Probing Multidrug Resistance P-glycoprotein Transporter Activity with SPECT Radiopharmaceuticals. Curr Top Med Chem 2010; 10(17): 1834-1845. |
Sun T, Gianino SM, Jackson E, Piwnica-Worms D, Gutmann DH, Rubin JB. CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice. J Neuroimmunol 2010; 224(1-2): 108-113. |
Warrington NM, Gianino SM, Jackson E, Goldhoff P, Garbow JR, Piwnica-Worms D, Gutmann DH, Rubin JB. Cyclic AMP Suppression Is Sufficient to Induce Gliomagenesis in a Mouse Model of Neurofibromatosis-1. Cancer Res 2010; 70(14): 5717-27. |
Ju JS, Miller SE, Jackson E, Cadwell K, Piwnica-Worms D, Weihl CC. Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Autophagy 2010; 6(5). |
Choi J, Ritchey J, Prior JL, Holt M, Shannon WD, Deych E, Piwnica-Worms DR, Dipersio JF. In vivo administration of hypomethylating agents mitigate graft-versus-host disease (GvHD) without sacrificing graft-versus-leukemia (GvL). Blood 2010; 116(1): 129-39. |
Harpstrite SE, Prior JL, Sivapackiam J, Collins SD, Rath NP, Sharma V. Synthesis, Characterization, and Molecular Structure of a Novel Zinc(II) Complex: Assessment of Impact of MDR1 Pgp Expression on its Cytotoxic Activity. Med Chem 2010; 6(4): 191-9. |
Sivapackiam J, Harpstrite SE, Prior JL, Gu H, Rath NP, Sharma V. Synthesis, molecular structure, and validation of metalloprobes for assessment of MDR1 P-glycoprotein-mediated functional transport. Dalton Trans 2010; 39(25): 5842-50. |
Yang KS, Macdonald-Obermann JL, Piwnica-Worms D, Pike LJ. Asp-960/Glu-961 control the movement of the C-terminal tail of the EGF receptor to regulate asymmetric dimer formation. J Biol Chem 2010; 285(31): 24014-22. |
Vikis HG, Jackson EN, Krupnick AS, Franklin A, Gelman AE, Chen Q, Piwnica-Worms D, You M. Strain-Specific Susceptibility for Pulmonary Metastasis of Sarcoma 180 Cells in Inbred Mice. Cancer Res 2010; 70(12): 4859-67. |
Morgan EA, Schneider JG, Baroni TE, Uluçkan O, Heller E, Hurchla MA, Deng H, Floyd D, Berdy A, Prior JL, Piwnica-Worms D, Teitelbaum SL, Ross FP, Weilbaecher KN. Dissection of platelet and myeloid cell defects by conditional targeting of the {beta}3-integrin subunit. FASEB J 2010; 24(4): 1117-27. |
Liu CC, Prior J, Piwnica-Worms D, Bu G. LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy. Proc Natl Acad Sci USA 2010; 107(11): 5136-41. |
Sondergaard CS, Hess DA, Maxwell DJ, Weinheimer C, Rosova I, Creer MH, Piwnica-Worms D, Kovacs A, Pederson L, Nolta JA. Human cord blood progenitors with high aldehyde dehydrogenase activity improve vascular density in a model of acute myocardial infarction. J Transl Med 2010; 8: 24. |
Banerjee S, Byrd JN, Gianino SM, Harpstrite SE, Rodriguez FJ, Tuskan RG, Reilly KM, Piwnica-Worms DR, Gutmann DH. The Neurofibromatosis Type 1 Tumor Suppressor Controls Cell Growth by Regulating Signal Transducer and Activator of Transcription-3 Activity In vitro and In vivo. Cancer Res 2010; 70(4): 1356-66. |
Rauch D, Gross S, Harding J, Bokhari S, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L. T-cell activation promotes tumorigenesis in inflammation-associated cancer. Retrovirology 2009; 6: 116. |
Naik S, Dothager RS, Marasa J, Lewis CL, Piwnica-Worms D. Vascular Endothelial Growth Factor Receptor-1 Is Synthetic Lethal to Aberrant {beta}-Catenin Activation in Colon Cancer. Clin Cancer Res 2009; 15(24): 7529-37. |
Ju JS, Fuentealba RA, Miller SE, Jackson E, Piwnica-Worms D, Baloh RH, Weihl CC. Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease. J Cell Biol 2009; 187(6): 875-88. |
Cao X, Leonard K, Collins LI, Cai SF, Mayer JC, Payton JE, Walter MJ, Piwnica-Worms D, Schreiber RD, Ley TJ. Interleukin 12 Stimulates IFN-{gamma}-Mediated Inhibition of Tumor-Induced Regulatory T-Cell Proliferation and Enhances Tumor Clearance. Cancer Res 2009; 69(22): 8700-9. |
Sivapackiam J, Gammon ST, Harpstrite SE, Sharma V. Targeted Chemotherapy in Drug Resistant Tumors and Noninvasive Imaging of P-Glycoprotein-Mediated Functional Transport in Cancer, and Emerging Role of Pgp in Neurodegenerative Diseases. In: Multi-Drug Resistance in Cancer (Methods in Molecular Biology). Zhou J (Ed.), Humana Press, New York, 2009; 596: 141-81. |
Jost SC, Collins L, Travers S, Piwnica-Worms D, Garbow JR. Measuring brain tumor growth: combined bioluminescence imaging-magnetic resonance imaging strategy. Mol Imaging 2009; 8(5): 245-53. |
Dothager RS, Piwnica-Worms D. Molecular imaging of pulmonary disease in vivo. Proc Am Thorac Soc 2009; 6(5): 403-10. |
Nervi B, Ramirez P, Rettig MP, Uy GL, Holt MS, Ritchey JK, Prior JL, Piwnica-Worms D, Bridger G, Ley TL, DiPersio JF. Chemosensitization of AML following mobilization by the CXCR4 antagonist AMD3100. Blood 2009; 113(21): 5340-51. |
Barnett EM, Zhang X, Maxwell D, Chang Q, Piwnica-Worms D. Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model. Proc Natl Acad Sci USA 2009; 106(23): 9391-6. |
Carreno BM, Garbow JR, Kolar GR, Jackson EN, Engelbach JA, Becker-Hapak M, Carayannopoulos LN, Piwnica-Worms D, Linette GP. Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases. Clin Cancer Res 2009; 15(10): 3277-86. |
Capoccia BJ, Robson DL, Levac KD, Maxwell DJ, Hohm SA, Neelamkavil MJ, Bell GI, Xenocostas A, Link DC, Piwnica-Worms D, Nolta JA, Hess DA. Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity. Blood 2009; 113(21): 5340-51. |
McDunn JE, Muenzer JT, Dunne B, Zhou A, Yuan K, Hoekzema A, Hilliard C, Chang KC, Davis CG, McDonough J, Hunt C, Grigsby P, Piwnica-Worms D, Hotchkiss RS. An anti-apoptotic peptide improves survival in lethal total body irradiation. Biochem Biophys Res Commun 2009; 382(4): 657-62. |
Hirbe AC, Roelofs AJ, Floyd DH, Deng H, Becker SN, Lanigan LG, Apicelli AJ, Xu Z, Prior JL, Eagleton MC, Piwnica-Worms D, Rogers MJ, Weilbaecher K. The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts. Bone 2009; 44(5): 908-16. |
Ju JS, Miller SE, Jackson E, Cadwell K, Piwnica-Worms D, Weihl CC. Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Autophagy 2009; 5(4): 511-9. |
Maxwell D, Chang Q, Zhang X, Barnett EM, Piwnica-Worms D. An Improved Cell-Penetrating, Caspase-Activatable, Near-Infrared Fluorescent Peptide for Apoptosis Imaging. Bioconjug Chem 2009 20(4): 702-9. |
Gammon ST, Villalobos VM, Roshal M, Samrakandi M, Piwnica-Worms D. Rational design of novel red-shifted BRET pairs: platforms for real-time single chain protease biosensors. Biotechnol Prog 2009 25(2): 559-69. |
Gross S, Gammon ST, Moss BL, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D. Bioluminescence imaging of myeloperoxidase actvity in vivo. Nat Med 2009 15(4): 455-61. |
Uluçkan O, Becker SN, Deng H, Zou W, Prior JL, Piwnica-Worms D, Frazier WA, Weilbaicher KN. CD47 Regulates Bone Mass and Tumor Metastasis to Bone. Cancer Res 2009; 69(7): 3196-3204. |
Yang KS, Ilagan MX, Piwnica-Worms D, Pike LJ. Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor. J Biol Chem 2009; 284(12): 7474-82. |
Dothager RS, Flentie KN, Moss BL, Pan D, Kesarwala AH, Piwnica-Worms D. Advances in bioluminescence imaging of live animal models. Curr Opin Biotechnol 2009; 20(1): 45-53. |
Rauch D, Gross S, Harding J, Niewiesk S, Lairmore M, Piwnica-Worms D, Ratner L. Imaging spontaneous tumorigenesis: Inflammation precedes development of peripheral NK tumors. Blood 2009; 113(7): 1493-500. |
Kesarwala AH, Samrakandi MM, Piwnica-Worms D. Proteasome inhibition blocks ligand-induced dynamic processing and internalization of EGFR via altered receptor ubiquitination and phosphorylation. Cancer Res 2009; 69(3): 976-83. |
Pazolli E, Luo X, Brehm S, Carbery K, Chang JJ, Prior JL, Doherty J, Demehri S, Salavaggione L, Piwnica-Worms D, Stewart SA. Senescent stromal-derived osteopontin promotes preneoplastic cell growth. Cancer Res 2009; 69(3): 1230-9. |
Parry JJ, Sharma V, Andrews R, Moros EG, Piwnica-Worms D, Rogers BE. PET imaging of heat-inducible suicide gene expression in mice bearing head and neck squamous cell carcinoma xenografts. Cancer Gene Ther 2009; 16(2): 161-70. |
Goldhoff P, Warrington NM, Limbrick DD Jr, Hope A, Woerner BM, Jackson E, Perry A, Piwnica-Worms D, Rubin JB. Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression. Clin Cancer Res 2008; 14(23): 7717-25. |
Pichler A, Prior JL, Luker GD, Piwnica-Worms D. Generation of a highly-inducible Gal4→Fluc universal reporter mouse for in vivo bioluminescence imaging. Proc Natl Acad Sci USA 2008; 105(41): 15932-7. |
Naik S, Moss BL, Pichler-Wallace A, Piwnica-Worms D. Imaging cellular networks and protein-protein interactions in vivo. In: Molecular Imaging in Oncology. Pomper M, Gelovani JT (Ed.), Informa Healthcare USA, New York, NY, 2008; in press. |
Flentie KN, Qi M, Gammon ST, Razia Y, Lui F, Marpegan L, Manglik A, Piwnica-Worms D, McKinney JS. Stably Integrated luxCDABE for Assessment of Salmonellae Invasion Kinetics. Mol Imaging 2008; 7(5): 222-33. |
Uluçkan O, Eagleton MC, Floyd DH, Morgan EA, Hirbe AC, Kramer M, Dowland N, Prior JL, Piwnica-Worms D, Jeong SS, Chen R, Weilbaecher K. APT102, a novel ADPase, cooperates with aspirin to disrupt bone metastasis in mice. J Cell Biochem 2008; 104(4): 1311-23. |
Moss BL, Gross S, Gammon ST, Vinjamoori A, Piwnica-Worms D. Identification of a ligand-induced transient refractory period in nuclear factor-kappaB signaling. J Biol Chem 2008; 283(13): 8687-98.
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Leevy WM, Gammon, ST, Johnson JR, Lampkins AJ, Jiang H, Marquez M, Piwnica-Worms D, Smith BD. Non-invasive optical imaging of Staphylococcus aureus bacterial infection in living mice using a bis-dipicolylamine-zinc(II) affinity group conjugated to a near infrared fluorophor. Bioconjug Chem 2008; 19(3): 686-92. |
McDunn JE, Muenzer JT, Rachdi L, Chang KC, Davis CG, Dunne WM, Piwnica-Worms D, Bernal-Mizrachi E, Hotchkiss RS. Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis. Fed Assoc Soc Exper Biol J 2008; 22(2): 561-8. |
Maxwell DJ, Bonde J, Hess DA, Hohm SA, Lahey R, Creer MH, Piwnica-Worms D, Nolta JA. Fluorophore-conjugated iron oxide nanoparticle labeling and analysis of engrafting human hematopoietic stem cells. Stem Cells 2008; 26(2): 517-24. |
Zhao L, Kroenke CD, Song J, Piwnica-Worms D, Ackerman JJ, Neil JJ. Intracellular water-specific MR of microbead-adherent cells: the HeLa cell intracellular water exchange lifetime. NMR Biomed 2008; 21(2): 159-64. |
Zhao L, Sukstanskii AL, Kroenke CD, Song J, Piwnica-Worms D, Ackerman JJ, Neil JJ. Intracellular water specific MR of microbead-adherent cells: HeLa cell intracellular water diffusion. Magn Reson Med 2008; 59(1): 79-84. |
Villalobos V, Naik S, Piwnica-Worms D. Detection of protein-protein interactions in live cells and animals with split Firefly luciferase protein fragment complementation. In: Methods in Molecular Biology, Vol 439: Genomics Protocols, 2nd Edition. Starkey M, Elaswarapu R. (Ed.), Humana Press, Totowa, NJ, 2008; pp. 339-52. |
Cheng KT, Piwnica-Worms D. Ac-rkkrrqrrrGK(QSY21)DEVDAPC(Alexa Fluor 647)-NH2 TCAPQ647. In: Molecular Imaging and Contrast Agent Database (MICAD) [database online]. National Library of Medicine (US), NCBI, Bethesda, MD, 2008; Available from: http://micad.nih.gov. |
Gross S, Moss BL, Piwnica-Worms D. Veni, vidi, vici: in vivo molecular imaging of immune response. Immunity 2007; 27(4):533-8. |
Piwnica-Worms, D. Spying on signal transduction and protein interactions. In: Molecular Imaging Gateway. Society of Nuclear Medicine MICoE, 2007. |
Pichler A, Piwnica-Worms D. Overview of Cardiovascular Molecular Imaging. In: Cardiovascular Molecular Imaging. Gropler RJ, Glover DK, Sinusas AJ, Taegtmeyer H (Ed.), Informa Healthcare USA, New York, NY, 2007, pp 1-8. |
Naik S, Piwnica-Worms D. Real-time imaging of beta-catenin dynamics in cells and living mice. Proc Natl Acad Sci USA 2007; 104(44): 17465-70. |
Gammon ST, Bernstein M, Schuster DP, Piwnica-Worms D. A method for quantification of nucleotides and nucleotide analogues in thymidine kinase assays utilizing lanthanum phosphate co-precipitation. Anal Biochem 2007; 369(1): 80-6. |
Cao X, Cai SF, Fehniger TA, Song J, Collins LI, Piwnica-Worms DR, Ley TJ. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity 2007; 27(4): 635-46. |
Harpstrite SE, Prior JL, Rath NP, Sharma V. Metalloprobes: Synthesis, characterization, and potency of a novel gallium(III) complex in human epidermal carcinoma cells. J Inorg Biochem 2007; 101(10): 1347-53. |
Hirbe A, Rubin J, Uluçkan O, Morgan E, Eagleton M, Prior J, Piwnica-Worms D, Weilbaecher K. Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone. Proc Natl Acad Sci USA 2007; 104(35): 14062-7. |
Villalobos V, Naik S, Piwnica-Worms D. Current state of imaging protein-protein interactions in vivo with genetically encoded reporters. Ann Rev Biomed Engineering 2007; 9: 321-49. |
Johnson JR, Fu N, Arunkumar E, Leevy WM, Gammon ST, Piwnica-Worms D, Smith BD. Squaraine rotaxanes: superior substitutes for Cy-5 in molecular probes for near-infrared fluorescence cell imaging. Angew Chem Int Ed 2007, 46(29): 5528-31. |
Nervi B, Rettig MP, Ritchey JK, Wang HL, Bauer G, Walker J, Herrbrich PE, Bonyhadi ML, Berenson RJ, Prior JL, Piwnica-Worms D, Nolta JA, DiPersio JF. Naive and ex vivo activated human T cells generate consistent engraftment and lethal graft-versus-host disease in NOD SCID b2m null mice: a novel xenogeneic GVHD model. Exper Hematol 2007; 35(12): 1823-38. |
Kashiwagi H, McDunn JE, Goedegebuure PS, Gaffney MC, Chang K, Trinkaus K, Piwnica-Worms D, Hotchkiss RS, Hawkins WG. TAT-Bim induces extensive apoptosis in cancer cells. Ann Surg Oncol 2007; 14(5): 1763-17. |
Yuan L, Siegel M, Choi K, Khosla C, Miller CR, Jackson EN, Piwnica-Worms D, Rich KM. Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene 2007; 26(18): 2563-73. |
Hirbe AC, Uluçkan O, Morgan EA, Eagleton MC, Prior JL, Piwnica-Worms D, Trinkaus K, Apicelli A, Weilbaecher K. Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner. Blood 2007; 109(8): 3424-31. |
Gross S, Abraham U, Prior JL, Herzog ED, Piwnica-Worms D. Continuous delivery of D-luciferin by implanted micro-osmotic pumps enables true real-time bioluminescence imaging of luciferase activity in vivo. Molec Imaging 2007; 6(2): 121-30. |
Bullok KE, Maxwell D, Kesarwala AH, Gammon S, Prior JL, Snow M, Stanley S, Piwnica-Worms D. Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. Biochemistry 2007; 46(13): 4055-65. |
Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci USA 2007; 104(13): 5680-5. |
Saxena MT, Aton SJ, Hildebolt C, Prior JL, Abraham U, Piwnica-Worms D, Herzog ED. Bioluminescence imaging of Period 1 gene expression in utero. Molec Imaging 2007; 6(1): 68-72. |
Yang L, Jackson E, Woerner BM, Perry A, Piwnica-Worms D, Rubin JB. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res 2007; 67(2): 651-8. |
Leevy WM, Gammon ST, Jiang H, Johnson JR, Maxwell DJ, Jackson EN, Marquez M, Piwnica-Worms D, Smith BD. Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe. J Am Chem Soc 2006; 128(51): 16476-7. |
Piwnica-Worms D, Kesarwala AH, Pichler A, Prior JL, Sharma V. Single photon emission computed tomography and psotron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease. In: Neuroimaging Clinics of North America: Molecular Neuroimaging. Schellingerhout D (Ed.), Elsevier, Philadelphia, PA, 2006; 16(4): 575-89. |
Kesarwala AH, Prior JL, Sun J, Harpstrite SE, Sharma V, Piwnica-Worms D. Second-generation triple reporter for bioluminescence, microPET, and fluorescence imaging. Molec Imaging 2006; 5(4):465-74. |
Ippolito JE, Merritt ME, Bäckhed F, Moulder KL, Mennerick S, Manchester JK, Gammon ST, Piwnica-Worms D, Gordon JI. Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers. Proc Natl Acad Sci USA 2006; 103(33): 12505-10. |
Gross S, Piwnica-Worms D. Molecular imaging strategies for drug discovery and development. Curr Opin Chem Biol 2006; 10(4): 334-42. |
Barnett EM, Elangovan B, Bullok KE, Piwnica-Worms D. Selective uptake of modified Tat peptide-fluorophore conjugates in rat retina in ex vivo and in vivo models. Invest Ophthal Visual Sci 2006; 47(6): 2589-95. |
Hotchkiss RS, McConnell KW, Bullok K, Davis CG, Chang KC, Schwulst S, Dunne JC, Dietz GP., Bähr M, McDunn JE, Karl IE, Coopersmith CM, Piwnica-Worms D. Tat-BH4 and Tat-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunology 2006; 176(9): 5471-7. |
Gammon ST, Leevy WM, Gross S, Gokel GW, Piwnica-Worms D. Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources. Anal Chem 2006; 78(5): 1520-7. |
Bullok KE, Gammon ST, Violini S, Prantner AM, Villalobos VM, Sharma V, Piwnica-Worms D. Permeation peptide conjugates for in vivo molecular imaging applications. Molec Imaging 2006; 5(1): 1-15. |
Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn, MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DH. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-w deposition in an Alzheimer's disease mouse model. J Clin Invest 2005; 115(11): 3285-90. |
Gross S, Piwnica-Worms D. Monitoring proteasome activity in cellulo and in living animals by bioluminescent imaging: technical considerations for design and use of genetically-encoded reporters. Methods Enzymol 2005; 399: 512-30. |
Leevy WM, Gammon ST, Levchenko T, Daranciang DD, Murillo O, Torchilin V, Piwnica-Worms D, Huettner JE, Gokel GW. Structure-activity relationships, kinetics, selectivity and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells. Organic Biomol Chem 2005; 3(19): 3544-50. |
Abraham U, Prior JL, Granados-Fuentes D, Piwnica-Worms DR, and Herzog ED. Independent circadian oscillations of Period1 in specific brain areas in vivo and in vitro. J Neurosci 2005; 25(31): 8620-26. |
Bullok K, Piwnica-Worms D. Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. J Med Chem 2005; 48(17): 5404-7. |
Gross S, Piwnica-Worms D. Real-time imaging of ligand-induced IKK activation in intact cells and in living mice. Nat Methods 2005; 2(8): 607-14. |
Pichler A, Zelcer N, Prior JL, Kuil AJ, Piwnica-Worms D. In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein. Clin Cancer Res 2005; 11(12): 4487-94. |
Gillies RJ, Hoffman JM, Lam KS, Menkens AE, Piwnica-Worms DR, Sullivan DC, Weissleder R. Meeting report: high-throughput technologies for in vivo imaging agents. Molec Imaging 2005; 4(2): 98-103. |
Sharma V, Prior JL, Belinsky MG, Kruh GD, Piwnica-Worms D. Characterization of a 67Ga/68Ga radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug resistant tumors and at the blood-brain barrier. J Nucl Med 2005; 46(2): 354-64. |
Bigott HM, Prior JL, Piwnica-Worms DR, Welch MJ. Imaging multidrug resistance P-glycoprotein transport function using microPET with technetium-94m-Sestamibi. Molec Imaging 2005; 4(1): 30-9. |
Gross S, Piwnica-Worms D. Spying on cancer: molecular imaging in vivo with genetically encoded reporters. Cancer Cell 2005; 7(1): 5-15. |
Sharma V, Piwnica-Worms D. Monitoring multidrug resistance P-glycoprotein drug transport activity with SPECT and PET radiopharmaceuticals. Topics Curr Chem 2005; 252: 155-78. |
Piwnica-Worms D, Luker KE, Villalobos VM. Molecular imaging of protein-protein interactions in living animals. In: Molecular Imaging of the Lungs. Schuster DP, Blackwell TS (Ed.), Taylor & Francis Group, LLC, Boca Raton, FL, 2005; 313-26. |
Piwnica-Worms D, Luker KE. Imaging protein-protein interactions in whole cells and living animals. In: Molecular Imaging - An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy. Bogdanov AA Jr, Licha K (Ed.), Ernst Schering Research Foundation, Springer-Verlag, Heidelberg, 2005; 35-41. |
Smith MC, Luker KE, Garbow JR, Prior JL, Jackson E, Piwnica-Worms D, Luker GD. CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 2004; 64(23): 8604-12. |
Sharma V. Radiopharmaceuticals for assessment of multidrug resistance P-glycoprotein-mediated drug transport activity. Bioconjugate Chem 2004; 15(6), 1464-74. |
Luker KE, Smith MC, Luker GD, Gammon ST, Piwnica-Worms H, Piwnica-Worms D. Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci USA 2004; 101(33): 12288-93. |
Rettig MP, Ritchey JK, Prior JL, Haug JS, Piwnica-Worms D, DiPersio JF. Kinetics of in vivo elimination of suicide gene expressing T cells affects engraftment, graft-versus-host disease, and the graft-versus-leukemia effect after allogeneic bone marrow transplantation. J Immunol 2004; 173(6): 3620-30. |
Luker KE, Piwnica-Worms D. Optimizing luciferase protein fragment complementation for bioluminescent imaging of protein-protein interactions in live cells and animals. Methods Enzymol 2004; 385: 349-60. |
Piwnica-Worms D, Schuster DP, Garbow JR. Molecular imaging of host-pathogen interactions in intact small animals. Cell Microbiol 2004; 6(4): 319-31. |
Richard JC, Zhou Z, Chen DL, Minton MA, Piwnica-Worms D, Factor P, Ponde DE, Schuster DP. Quantification of pulmonary transgene expression with PET imaging. J Nucl Med 2004; 45(4): 644-54. |
Pichler A, Prior JL, Piwnica-Worms D. Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Natl Acad Sci USA 2004 101(6): 1702-07. |
Schuster DP, Kovacs A, Garbow J, Piwnica-Worms D. Recent advances in imaging the lungs of intact small animals. Am J Resp Cell Molec Biol 2004; 30(2): 129-38. |
Zhao H, Doyle TC, Wong RJ, Cao Y, Stevenson DK, Piwnica-Worms D, Contag CH. Characterization of coelenterazine analogs for measurements of Renilla luciferase activity in live cells and living animals. Molec Imaging 2004; 3(1): 43-54. |
Piwnica-Worms D. Introduction to molecular imaging. J Am College Radiol 2004; 1(1 Suppl): 2-3. |
Prantner AM, Sharma V, Garbow JR, Piwnica-Worms D. Synthesis and characterization of a Gd-DOTA-D-permeation peptide for magnetic resonance relaxation enhancement of intracellular targets. Molec Imaging 2003; 2(4): 333-41. |
Luker GD, Pica CM, Song J, Luker KE, Piwnica-Worms D. Imaging 26S proteasome activity and inhibition in living mice. Nat Med 2003 9(7): 969-73. |
Richard JC, Zhou Z, Ponde DE, Dence CS, Factor P, Reynolds PN, Luker GD, Sharma V, Ferkol T, Piwnica-Worms D, Schuster DP. Imaging pulmonary transgene expression with positron emission tomography. Am J Respir Crit Care Med 2003; 167(9): 1257-63. |
Luker GD, Sharma V, Pica CM, Prior JL, Li W, Piwnica-Worms D. Molecular imaging of protein-protein interactions: controlled expression of p53 and large T antigen fusion proteins in vivo. Cancer Res 2003; 63(8): 1780-8. |
Gammon ST, Villalobos VM, Prior JL, Sharma V, Piwnica-Worms D. Quantitative analysis of permeation peptide complexes labeled with Technetium-99m: chiral and sequence-specific effects on net cell uptake. Bioconjug Chem 2003; 14(2): 368-76. |
Luker GD, Sharma V, Piwnica-Worms D. Visualizing protein-protein interactions in living animals. Methods 2003; 29(1): 110-22. |
Ocheskey JA, Polyakov V, Harpstrite SE, Oksman A, Goldberg DE, Piwnica-Worms D, Sharma V. Synthesis, characterization, and molecular structure of a gallium(III) complex of an amine-phenol ligand with activity against chloroquine-sensitive Plasmodium falciparum strains. J Inorg Biochem 2003; 93(3-4): 265-70. |
Luker GD, Sharma V, Piwnica-Worms D. Noninvasive imaging of protein-protein interactions in living animals. In: Handbook of Proteomic Methods. Conn PM (Ed.), Humana Press Inc., Totowa, New Jersey, 2003; pp. 283-98. |
Piwnica-Worms D. Perspectives in imaging: present and future prospects of clinical molecular imaging. In: Holland-Frei Cancer Medicine e.6. Kufe, D, Pollock RE, Weichselbaum RR, Bast RC, Gansler T, Holland JF, Frei E (Ed.), B.C. Decker, Inc., Hamilton, Ontario, 2003; pp. 551-56. |
Piwnica-Worms D, Luker GD, Anderson C, Wahl RL. Molecular imaging in oncology. In: Molecular Nuclear Medicine: The Challenge of Genomics and Proteomics to Clinical Practice. Feinendegen LE, Shreeve WW, Eckelman WC, Bahk YW, Wagner HN Jr (Ed.), Springer-Verlag, Heidelberg, 2003; 633-651. |
Bullok KE, Dyszlewski M, Prior JL, Pica CM, Sharma V, Piwnica-Worms D. Characterization of novel histidine-tagged Tat-peptide complexes dual-labeled with (99m)Tc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy. Bioconjug Chem 2002; 13(6): 1226-37. |
Luker GD, Bardil JP, Prior JL, Pica CM, Piwnica-Worms D, Leib DA. Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice. J Virol 2002; 76(23): 12149-61. |
Violini S, Sharma V, Prior JL, Dyszlewski M, Piwnica-Worms D. Evidence for a plasma membrane-mediated permeability barrier to Tat basic domain in well-differentiated epithelial cells: lack of correlation with heparan sulfate. Biochemistry 2002; 41(42): 12652-61. |
Sharma V, Luker GD, Piwnica-Worms D. Molecular imaging of gene expression and protein function in vivo with PET and SPECT. J Magn Reson Imaging 2002; 16(4): 336-51. |
Luker GD, Sharma V, Pica CM, Dahlheimer JL, Li W, Ocheskey J, Ryan CE, Piwnica-Worms H, Piwnica-Worms D. Noninvasive imaging of protein-protein interactions in living animals. Proc Natl Acad Sci USA 2002; 99(10): 6961-6. |
Luker GD, Luker KE, Sharma V, Pica CM, Dahlheimer JL, Ocheskey J, Fahrner TJ, Milbrandt J, Piwnica-Worms D. In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1a promoter. Molec Imaging 2002; 1(2): 65-73. |
Dyszlewski M, Blake HM, Dahlheimer JL, Pica CM, Piwnica-Worms D. Characterization of a novel 99mTc-carbonyl complex as a functional probe of MDR1 P-glycoprotein transport activity. Molec Imaging 2002; 1(1): 24-35. |
Luker GD, Flagg TP, Sha Q, Luker KE, Pica CM, Nichols CG, Piwnica-Worms D. MDR1 P-glycoprotein reduces influx of substrates without affecting membrane potential. J Biol Chem 2001; 276(52): 49053-60. |
Luker KE, Pica CM, Schreiber RD, Piwnica-Worms D. Overexpression of IRF9 confers resistance to antimicrotubule agents in breast cancer cells. Cancer Res 2001; 61(17): 6540-7. |
Luker GD, Dahlheimer JL, Ostlund RE Jr, Piwnica-Worms D. Decreased hepatic accumulation and enhanced esterification of cholesterol in mice deficient in mdr1a and mdr1b P-glycoproteins. J Lipid Res 2001; 42(9): 1389-94. |
Slapak CA, Dahlheimer J, Piwnica-Worms D. Reversal of multidrug resistance with LY335979: functional analysis of P-glycoprotein-mediated transport activity and its modulation in vivo. J Clin Pharmacol 2001; Suppl: 29S-38S. |
Luker GD, Piwnica-Worms D. Beyond the genome: molecular imaging in vivo with PET and SPECT. Acad Radiol 2001; 8: 4-14. |
Piwnica-Worms D. Molecular imaging in the postgenomic era. Imaging Economics. CurAnt Communications, Inc., Los Angeles, 2001; 14: 12-16. |
Piwnica-Worms D, Luker KE, Fracasso PM. Multidrug resistance, Part A: Breast cancer. In: Nuclear Oncology. Khalkhali I, Maublant J, Goldsmith SJ (Ed.), Lippincott Williams & Wilkins, Philadelphia, 2001; 63-72. |
Polyakov V, Sharma V, Dahlheimer JL, Pica CM, Luker GD, Piwnica-Worms D. Novel Tat-peptide chelates for direct transduction of technetium-99m and rhenium into human cells for imaging and radiotherapy. Bioconjug Chem 2000; 11(6): 762-71. |
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Tan B, Piwnica-Worms D, Ratner L. Multidrug resistance transporters and modulation. Curr Opin Oncol 2000; 12(5): 450-8. |
Chen WS, Luker KE, Dahlheimer JL, Pica CM, Luker GD, Piwnica-Worms D. Effects of MDR1 and MDR3 P-glycoproteins, MRP1, and BCRP/MXR/ABCP on transport of (99m)Tc-tetrofosmin. Biochem Pharmacol 2000; 60(3): 413-26. |
Luker GD, Pica CM, Kumar AS, Covey DF, Piwnica-Worms D. Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains. Biochemistry 2000; 39(29): 7651-61. |
Sharma V, Beatty A, Wey SP, Dahlheimer J, Pica CM, Crankshaw CL, Bass L, Green MA, Welch MJ, Piwnica-Worms D. Novel gallium(III) complexes transported by MDR1 P-glycoprotein: potential PET imaging agents for probing P-glycoprotein-mediated transport activity in vivo. Chem Biol 2000; 7(5): 335-43. |
Piwnica-Worms D. Functional identification of multidrug resistance gene expression in vivo. In: American Society of Clinical Oncology Spring 2000 Educational Book. ASCO Publications and Lippincott Williams & Wilkins, Baltimore, 2000; 178-84. |
Piwnica-Worms D, Luker GD, Luker KE, Rao VV, Sharma V. Imaging gene expression in cancer: functional identification of multidrug resistance (MDR1) P-glycoprotein in vivo. In: Medical Radiology - Diagnostic Imaging and Radiation Oncology: Diagnostic Nuclear Medicine. Schiepers C (Ed.), Springer-Verlag, Heidelberg, 2000; 273-83. |
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