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Naik, S., Piwnica-Worms, D. Real-time imaging of b-catenin dynamics in cells and living mice. Proc Nat’l Acad Sci USA 2007; 104:17465-17470. |
PubMed Link |
Cao, X., Cai, S.F., Fehniger, T.A., Song, J., Collins, L.I., Piwnica-Worms, D.R., Ley, T.J. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity 2007; 27: 635-646. |
PubMed Link |
Villalobos, V., Naik, S., Piwnica-Worms, D. Current state of imaging protein-protein interactions in vivo with genetically encoded reporters. Ann Rev Biomed Engineering 2007, 9:321-349. |
PubMed Link |
Johnson, J.R., Fu, N., Arunkumar, E., Leevy, W.M., Gammon, S.T., Piwnica-Worms, D., Smith, B.D. Near-infrared fluorescence imaging of eukaryotic and prokaryotic cells using squaraine-rotaxane molecular probes. Angew Chem Int Ed 2007, 46:5528-5531. |
PubMed Link |
Hurov, J.B., Huang, M., White, L.S., Lennerz, J., Choi, C.S., Cho, Y.-R., Kim, H.-J., Prior, J.L., Piwnica-Worms, D., Cantley, L.C., Kim, J.K., Shulman, G.I., Piwnica-Worms, H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Nat’l Acad Sci USA 2007; 104:5680-5685. |
PubMed Link |
Gross, S., Abraham, U., Prior, J.L., Herzog, E.D., Piwnica-Worms, D. Continuous delivery of D-luciferin by implanted micro-osmotic pumps enables true real-time bioluminescence imaging of luciferase activity in vivo. Molec Imaging 2007; 6:121-130. |
PubMed Link |
Bullok, K.E., Maxwell, D., Kesarwala, A.H., Gammon, S., Prior, J.L., Snow, M., Stanley, S., Piwnica-Worms, D. Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. Biochemistry 2007; 46:4055-4065. |
PubMed Link |
Gammon, S.T., Leevy, W.M., Gross, S., Gokel, G.W., Piwnica-Worms, D. Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources. Anal Chem 2006; 78:1520-1527. |
PubMed Link |
Cirrito, J.R., Deane, R., Fagan, A.M., Spinner, M.L., Parsadanian, M., Finn, M.B., Jiang, H., Prior, J.L., Sagare, A., Bales, K.R., Paul, S.M., Zlokovic, B.V., Piwnica-Worms, D., Holtzman, D.H. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-w deposition in an Alzheimer’s disease mouse model. J Clin Invest 2005; 115:3285-3290. |
PubMed Link |
Gross S, Piwnica-Worms D. Spying on cancer: molecular imaging in vivo with genetically encoded reporters. Cancer Cell 2005 7:5-15. |
PubMed Link |
Gross S, Piwnica-Worms D. Real-time imaging of ligand-induced IKK activation in intact cells and in living mice. Nature Methods 2005 2:607-614. |
PubMed Link |
Luker KE, Luker GD, Smith MCP, Gammon ST, Piwnica-Worms H, Piwnica-Worms D. Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Natl Acad Sci USA 2004 101:12288-12293. |
PubMed Link |
Pichler A, Prior JL, Piwnica-Worms D. Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Natl Acad Sci USA 2004 101:1702-1707. |
PubMed Link |
Luker GD, Pica CM, Song J, Luker KE, Piwnica-Worms D. Imaging 26S proteasome activity and inhibition in living mice. Nature Medicine 2003 9:969-973. |
PubMed Link |
Moss BL, Gross S, Gammon ST, Vinjamoori A, Piwnica-Worms D. Identification of a ligand-induced transient refractory period in nuclear factor-kappa B signaling. J Biol Chem 2008; in press. |
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Naik, S., Moss, B.L., Pichler-Wallace, A., Piwnica-Worms, D. Imaging cellular networks and protein-protein interactions in vivo. In: Textbook of Molecular Imaging in Oncology. Pomper, M., Gelovani, J.T. (editors), Informa Healthcare USA, New York, NY, 2008; in press. |
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Gross S, Moss BL, Piwnica-Worms D. Veni, vidi, vici: in vivo molecular imaging of immune response. Immunity 2007; Oct 27(4):533-8. |
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Piwnica-Worms, D. Spying on signal transduction and protein interactions. In: Molecular Imaging Gateway. Society of Nuclear Medicine MICoE, 2007 |
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Pichler, A., Piwnica-Worms, D. Overview of Cardiovascular Molecular Imaging. In: Cardiovascular Molecular Imaging. Gropler, R.J., Glover, D.K., Sinusas, A.J., Taegtmeyer, H. (editors), Informa Healthcare USA, New York, NY, 2007, pp 1-8 |
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Naik, S., Piwnica-Worms, D. Real-time imaging of b-catenin dynamics in cells and living mice. Proc Nat’l Acad Sci USA 2007; 104:17465-17470. |
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Gross, S., Moss, B.L., Piwnica-Worms, D. Veni, vidi, vici: in vivo molecular imaging of immune response. Immunity 2007; 27: 533-538. |
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Leevy, W.M., Gammon, S.T., Johnson, J.R., Lampkins, A.J., Jiang, H., Marquez, M., Piwnica-Worms, D., Smith, B.D. Non-invasive optical imaging of Staphylococcus aureus bacterial infection in living mice using a bis-dipicolylamine-zinc(II) affinity group conjugated to a near infrared fluorophor. Bioconjug Chem 2007; in press. |
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Maxwell, D.J., Bonde, J., Hess, D.A., Hohm, S.A., Lahey, R., Creer, M.H., Piwnica-Worms, D., Nolta, J.A. Fluorophore conjugated iron oxide nanoparticle labeling and analysis of engrafting human hematopoietic stem cells. Stem Cells 2007; in press. |
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Zhao, L., Sukstanskii, A.L., Kroenke, C.D., Song, J., Piwnica-Worms, D., Ackerman, J.J.H., Neil, J.J. Intracellular water specific MR of microbead-adherent cells: HeLa cell intracellular water diffusion. Magn Reson Med 2007; in press. |
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Cao, X., Cai, S.F., Fehniger, T.A., Song, J., Collins, L.I., Piwnica-Worms, D.R., Ley, T.J. Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance. Immunity 2007; 27: 635-646. |
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Hirbe, A., Rubin, J., Uluckan, O., Morgan, E., Eagleton, M., Prior, J., Piwnica-Worms, D., Weilbaecher, K. Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone. Proc Nat’l Acad Sci USA 2007, in press. |
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Gammon, S.T., Bernstein, M., Schuster, D.P., Piwnica-Worms, D. A method for quantification of nucleotides and nucleotide analogues in thymidine kinase assays utilizing lanthanum phosphate co-precipitation. Anal Biochem 2007, in press. |
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Johnson, J.R., Fu, N., Arunkumar, E., Leevy, W.M., Gammon, S.T., Piwnica-Worms, D., Smith, B.D. Near-infrared fluorescence imaging of eukaryotic and prokaryotic cells using squaraine-rotaxane molecular probes. Angew Chem Int Ed 2007, in press. |
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McDunn, J.E., Muenzer, J.T., Rachdi, L., Chang, K.C., Davis, C.G., Dunne, W.M., Piwnica-Worms, D., Bernal-Mizrachi, E., Hotchkiss, R.S. Peptide-mediated activation of Akt and ERK signaling prevents lymphocyte apoptosis. Fed Assoc Soc Exper Biol J 2007; in press. |
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Villalobos, V., Naik, S., Piwnica-Worms, D. Current state of imaging protein-protein interactions in vivo with genetically encoded reporters. Ann Rev Biomed Engineering 2007, 9:321-349. |
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Villalobos, V., Naik, S., Piwnica-Worms, D. Detection of protein-protein interactions in live cells and animals with split Firefly luciferase protein fragment complementation. Methods Molec Biol: Genomics Protocols 2007, in press. |
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Nervi, B., Rettig, M.P., Ritchey, J.K., Wang, H.L., Bauer, G., Walker, J., Herrbrich, P.E., Bonyhadi, M.L., Berenson, R.J., Prior, J.L., Piwnica-Worms, D., Nolta, J.A., DiPersio, J.F. Naive and ex vivo activated human T cells generate consistent engraftment and lethal graft-versus-host disease in NOD SCID b2m null mice: a novel xenogeneic GVHD model. Exper Hematol 2007; in press. |
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Hurov, J.B., Huang, M., White, L.S., Lennerz, J., Choi, C.S., Cho, Y.-R., Kim, H.-J., Prior, J.L., Piwnica-Worms, D., Cantley, L.C., Kim, J.K., Shulman, G.I., Piwnica-Worms, H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Nat’l Acad Sci USA 2007; 104:5680-5685. |
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Bullok, K.E., Maxwell, D., Kesarwala, A.H., Gammon, S., Prior, J.L., Snow, M., Stanley, S., Piwnica-Worms, D. Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. Biochemistry 2007; 46:4055-4065. |
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Zhao, L., Kroenke, C.D., Song, J., Piwnica-Worms, D., Ackerman, J.J.H., Neil, J.J. Intracellular water-specific MR of microbead-adherent cells: the HeLa cell intracellular water exchange lifetime. NMR Biomed 2007, in press. |
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Hirbe, A.C., Uluçkan, O., Morgan, E.A., Eagleton, M.C., Prior, J.L., Piwnica-Worms, D., Trinkaus, K., Apicelli, A., Weilbaecher, K. Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner. Blood 2007; 109:3424-3431. |
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Kashiwagi, H., McDunn, J.E., Goedegebuure, P.S., Gaffney, M.C., Chang, K., Trinkaus, K., Piwnica-Worms, D., Hotchkiss, R.S., Hawkins, W.G. TAT-Bim induces extensive apoptosis in cancer cells. Ann Surg Oncol 2007; 14:1763-1771. |
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Saxena, M.T., Aton, S.J., Hildebolt, C., Prior, J.L., Abraham, U., Piwnica-Worms, D., Herzog, E.D. Bioluminescence imaging of Period 1 gene expression in utero. Molec Imaging 2007; 6:68-72. |
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Yang, L., Jackson, E., Woerner, B.M., Perry, A., Piwnica-Worms, D., Rubin, J.B. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res 2007; 67:651-658. |
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Gross, S., Abraham, U., Prior, J.L., Herzog, E.D., Piwnica-Worms, D. Continuous delivery of D-luciferin by implanted micro-osmotic pumps enables true real-time bioluminescence imaging of luciferase activity in vivo. Molec Imaging 2007; 6:121-130. |
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Yuan, L., Siegel, M., Choi, K., Khosla, C., Miller, C.R., Jackson, E.N., Piwnica-Worms, D., Rich, K.M. Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene 2007; 26:2563-2573. |
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Leevy, W.M., Gammon, S.T., Jiang, H., Johnson, J.R., Maxwell, D.J., Jackson, E.N., Marquez, M., Piwnica-Worms, D., Smith, B.D. Optical imaging of bacterial infection in living mice using a fluorescent near-infrared molecular probe. J Am Chem Soc 2006; 128:16476-16477. |
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Ippolito, J.E., Merritt, M.E., Bäckhed, F., Moulder, K.L., Mennerick, S., Manchester, J.K., Gammon, S.T., Piwnica-Worms, D., Gordon, J.I. Linkage between cellular communications, energy utilization, and proliferation in metastatic neuroendocrine cancers. Proc Nat’l Acad Sci USA 2006; 103:12505-12510. |
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Gross, S., Piwnica-Worms, D. Molecular imaging strategies for drug discovery and development. Curr Opin Chem Biol 2006; 10:334-342. |
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Kesarwala, A.H., Prior, J.L., Sun, J., Harpstrite, S.E., Sharma, V., Piwnica-Worms, D. Second-generation triple reporter for bioluminescence, microPET, and fluorescence imaging. Molec Imaging 2006; 5:465-474. |
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Gammon, S.T., Leevy, W.M., Gross, S., Gokel, G.W., Piwnica-Worms, D. Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources. Anal Chem 2006; 78:1520-1527. |
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Barnett, E.M., Elangovan, B., Bullok K.E., Piwnica-Worms, D. Selective uptake of modified Tat peptide-fluorophore conjugates in rat retina in ex vivo and in vivo models. Invest Ophthal Visual Sci 2006; 47:2589-2595. |
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Bullok, K.E., Gammon, S.T., Violini, S., Prantner, A.M., Villalobos, V.M., Sharma, V., Piwnica-Worms, D., Permeation peptide conjugates for in vivo molecular imaging applications. Molec Imaging 2006; 5:1-15. |
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Hotchkiss, R.S., McConnell, K.W., Bullok, K., Davis, C.G., Chang, K.C., Schwulst, S., Dunne, J.C., Dietz, G.P.H., Bähr, M., McDunn, J.E., Karl, I.E., Coopersmith, C.M., Piwnica-Worms, D. Tat-BH4 and Tat-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo. J Immunology 2006; 176:5471-5477. |
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Piwnica-Worms, D., Kesarwala, A.H., Pichler, A., Prior, J.L., Sharma, V. SPECT and PET imaging of multidrug resistant P-glycoprotein: monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer’s disease. In: Neuroimaging Clinics of North America: Molecular Neuroimaging. Schellingerhout, D. (Ed.), Elsevier, Philadelphia, PA, 2006; 16: 575-589. |
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Gross, S., Piwnica-Worms, D. Real-time imaging of ligand-induced IKK activation in intact cells and in living mice. Nature Methods 2005; 2:607-614. |
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Cirrito, J.R., Deane, R., Fagan, A.M., Spinner, M.L., Parsadanian, M., Finn, M.B., Jiang, H., Prior, J.L., Sagare, A., Bales, K.R., Paul, S.M., Zlokovic, B.V., Piwnica-Worms, D., Holtzman, D.H. P-glycoprotein deficiency at the blood-brain barrier increases amyloid-b deposition in an Alzheimer’s disease mouse model. J Clin Invest 2005; 115:3285-3290. |
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Gross, S., Piwnica-Worms, D. Monitoring proteasome activity in cellulo and in living animals by bioluminescent imaging: technical considerations for design and use of genetically-encoded reporters. Methods Enzymol 2005; 399:512-530. |
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Abraham, U., Prior, J.L., Granados-Fuentes, D., Piwnica-Worms, D.R., and Herzog, E.D. Independent circadian oscillations of Period1 in specific brain areas in vivo and in vitro. J Neuroscience 2005; 25:8620-8626. |
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Leevy, W.M., Gammon, S.T., Levchenko, T., Daranciang, D.D., Murillo, O., Torchilin, V., Piwnica-Worms, D., Huettner, J.E., Gokel, G.W. Structure-activity relationships, kinetics, selectivity and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells. Organic Biomol Chem 2005; 3:3544-3550. |
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Gillies, R.J., Hoffman, J.M., Lam, K.S., Menkens, A.E., Piwnica-Worms, D.R., Sullivan, D.C., Weissleder, R. Meeting report: high-throughput technologies for in vivo imaging agents. Molec Imaging 2005; 4: 98-103. |
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Bullok, K., Piwnica-Worms, D. Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis. J Med Chem 2005; 48:5404-5407. |
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Pichler, A., Zelcer, N., Prior, J.L., Kuil, A.J., Piwnica-Worms, D. In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein. Clin Cancer Res 2005; 11:4487-4494. |
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Gross, S., Piwnica-Worms, D. Spying on cancer: molecular imaging in vivo with genetically encoded reporters. Cancer Cell 2005; 7:5-15. |
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Bigott, H.M., Prior, J.L., Piwnica-Worms, D.R., Welch, M.J. Imaging multidrug resistance P-glycoprotein transport function using microPET with technetium-94m-Sestamibi. Molec Imaging 2005; 4:30-39. |
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Sharma, V., Prior, J.L., Belinsky, M.G., Kruh, G.D., Piwnica-Worms, D. Characterization of a gallium-67/gallium-68 radiopharmaceutical for SPECT and PET imaging of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug resistant tumors and at the blood-brain barrier. J Nucl Med 2005; 46: 354-364. |
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Sharma, V., Piwnica-Worms, D. Monitoring multidrug resistance P-glycoprotein drug transport activity with SPECT and PET radiopharmaceuticals. Topics Curr Chem 2005; 252:155-178. |
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Piwnica-Worms, D., Luker, K.E, Villalobos, V.M. Molecular imaging of protein-protein interactions in living animals. In: Molecular Imaging of the Lungs. Schuster, D.P., Blackwell, T.S. (editors), Taylor & Francis Group, LLC, Boca Raton, FL, 2005, pp. 313-326. |
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Piwnica-Worms, D., Luker, K.E. Imaging protein-protein interactions in whole cells and living animals. In: Molecular Imaging - An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy. Bogdanov Jr., A.A., Licha, K. (editors), Ernst Schering Research Foundation, Springer-Verlag, Heidelberg, 2005; pp. 35-41. |
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Smith, M.C.P., Luker, K.E., Garbow, J.R., Prior, J.L., Jackson, E., Piwnica-Worms, D., Luker, G.D. CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 2004; 64:8604-8612. |
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Luker, K.E., Luker, G.D., Smith, M.C.P., Gammon, S.T., Piwnica-Worms, H., Piwnica-Worms, D. Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals. Proc Nat’l Acad Sci USA 2004; 101:12288-12293. |
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Rettig, M.P., Ritchey, J.K., Prior, J.L. Haug, J.S., Piwnica-Worms, D., DiPersio, J.F. Kinetics of in vivo elimination of suicide gene expressing T cells affects engraftment, graft-versus-host disease, and the graft-versus-leukemia effect after allogeneic bone marrow transplantation. J Immunology 2004; 173:3620-3630. |
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Piwnica-Worms, D., Schuster, D.P., Garbow, J.R. Molecular imaging of host-pathogen interactions in intact small animals. Cell Microbiol 2004; 6:319-331. |
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Zhao, H., Doyle, T.C., Wong, R.J., Cao, Y., Stevenson, D.K., Piwnica-Worms, D., Contag, C.H. Characterization of coelenterazine analogs for measurements of Renilla luciferase activity in live cells and living animals. Molec Imaging 2004; 3:43-54. |
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Pichler, A., Prior, J.L., Piwnica-Worms, D. Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine. Proc Nat’l Acad Sci USA 2004; 101:1702-1707. |
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Luker, K.E, Piwnica-Worms, D. Optimizing luciferase protein fragment complementation for bioluminescent imaging of protein-protein interactions in live cells and animals. Methods Enzymol 2004; 385:349-360. |
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Richard, J.-C., Zhou, Z., Chen, D.L., Minton, M.A., Piwnica-Worms, D., Factor, P., Ponde, D.E., Schuster, D.P. Quantification of pulmonary transgene expression with PET imaging. J Nucl Med 2004; 45:644-654. |
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Piwnica-Worms, D. Introduction to molecular imaging. J Am College Radiol 2004; S1:2-3. |
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Schuster, D.P., Kovacs, A., Garbow, J., Piwnica-Worms, D. Recent advances in imaging the lungs of intact small animals. Am J Resp Cell Molec Biol 2004; 30:129-38. |
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Luker, G.D., Pica, C.M., Song, J., Luker, K.E., Piwnica-Worms, D. Imaging 26S proteasome activity and inhibition in living mice. Nature Med 2003; 9:969-973. |
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Prantner, A.M., Sharma, V., Piwnica-Worms, D. Synthesis and characterization of a Gd-DOTA-D-permeation peptide for magnetic resonance relaxation enhancement of intracellular targets. Molec Imaging 2003; 2:333-341. |
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Richard, J-C., Zhou, Z., Ponde, D.E., Dence, C.S., Factor, P., Reynolds, P.N., Luker, G.D., Sharma, V., Ferkol, T., Piwnica-Worms, D., Schuster, D.P. Imaging pulmonary transgene expression with positron emission tomography. Am J Respir Crit Care Med 2003; 167:1257-1263. |
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Luker, G.D., Sharma, V., Pica, C.M., Prior, J.L., Li, W., Piwnica-Worms, D. Molecular imaging of protein-protein interactions: controlled expression of p53 and large T antigen fusion proteins in vivo. Cancer Res 2003; 63:1780-1788. |
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Gammon, S.T., Villalobos, V.M., Prior, J.L., Sharma, V., Piwnica-Worms, D. Quantitative analysis of permeation peptide complexes labeled with technetium-99m: chiral and sequence-specific effects on net cell uptake. Bioconjug Chem 2003; 14:368-376. |
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Luker, G.D., Sharma, V., Piwnica-Worms, D. Visualizing protein-protein interactions in living animals. Methods 2003; 29:110-122. |
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Ocheskey, J.A., Polyakov, V., Oksman, A., Goldberg, D.E., Piwnica-Worms, D., Sharma, V. Synthesis, characterization, and molecular structure of a gallium(III) complex of an amine-phenol ligand with activity against chloroquine-sensitive P. falciparum strains. J Inorg Biochem 2003; 93:265-270. |
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Luker, G.D., Sharma, V., Piwnica-Worms, D. Noninvasive imaging of protein-protein interactions in living animals. In: Handbook of Proteomic Methods. P. Michael Conn (editor), Humana Press Inc., Totowa, New Jersey, 2003; pp. 283-298. |
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Piwnica-Worms, D. Perspectives in imaging: present and future prospects of clinical molecular imaging. In: Holland-Frei Cancer Medicine e.6. Kufe, D., Pollock, R.E., Weichselbaum, R.R., Bast, R.C., Gansler, T., Holland, J.F., Frei, E. (editors), B.C. Decker, Inc., Hamilton, Ontario, 2003; pp. 551-556. |
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Piwnica-Worms, D., Luker, G.D., Anderson, C., Wahl, R.L. Molecular imaging in oncology. In: Molecular Nuclear Medicine: The Challenge of Genomics and Proteomics to Clinical Practice. Feinendegen, L.E., Shreeve, W.W., Eckelman, W.C., Bahk, Y.-W., Wagner, H.N. Jr. (editors), Springer-Verlag, Heidelberg, 2003; 633-651. |
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Bullok, K.E., Dyszlewski, M., Prior, J.L., Pica, C.M., Sharma, V., Piwnica-Worms, D. Characterization of novel histidine-tagged Tat-peptide complexes dual-labeled with 99mTc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy. Bioconjug Chem 2002; 13:1226-1237. |
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Luker, G.D., Bardil, P., Prior, J.L., Pica, C.M., Piwnica-Worms, D., Leib, D.A. Noninvasive bioluminescence imaging of herpes simplex virus type 1 (HSV-1) infection and therapy in living mice. J Virol 2002; 76:12149-12161. |
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Violini, S., Sharma, V., Prior, J.L., Dyszlewski, M., Piwnica-Worms, D. Evidence for a plasma membrane-mediated permeability barrier to Tat basic domain in well-differentiated epithelial cells: lack of correlation with heparan sulfate. Biochemistry 2002; 41:12652-12661. |
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Luker, G.D., Sharma, V., Pica, C.M., Dahlheimer, J.L., Li, W., Ocheskey, J., Ryan, C.E., Piwnica-Worms, H., Piwnica-Worms, D. Noninvasive imaging of protein-protein interactions in living animals. Proc Nat’l Acad Sci USA 2002; 99:6961-6966. |
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Luker, G.D., Luker, K.E., Sharma, V., Pica, C.M., Dahlheimer, J.L., Ocheskey, J., Fahrner, T.J., Milbrandt, J., Piwnica-Worms, D. In vitro and in vivo characterization of a dual-function green fluorescent protein-HSV1-thymidine kinase reporter gene driven by the human elongation factor 1a promoter. Molec Imaging 2002; 1:65-73. |
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Sharma, V., Luker, G.D., Piwnica-Worms, D. Molecular imaging of gene expression and protein function in vivo with PET and SPECT. J Mag Reson Imaging 2002; 16:336-351. |
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Dyszlewski, M., Blake, H.M., Dahlheimer, J.L., Pica, C.M., Piwnica-Worms, D. Characterization of a novel 99mTc-carbonyl complex as a functional probe of MDR1 P-glycoprotein transport activity. Molec Imaging 2002; 1:24-35. |
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Luker, G.D., Flagg, T.P., Sha, Q., Luker, K.E., Pica, C.M., Nichols, C.G., Piwnica-Worms, D. MDR1 P-glycoprotein reduces influx of substrates without affecting membrane potential. J Biol Chem 2001; 276:49053-49060. |
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Luker, K.E., Pica, C.M., Schreiber, R.D., Piwnica-Worms, D. Constitutive overexpression of IRF9 confers resistance to antimicrotubule agents in breast cancer cells. Cancer Res 2001; 61:6540-6547. |
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Slapak, C.A., Dahlheimer, J., Piwnica-Worms, D. Reversal of multidrug resistance with LY335979: functional analysis of P-glycoprotein-mediated transport activity and its modulation in vivo. J Clin Pharmacol 2001; 41:29S-38S. |
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Luker, G.D., Piwnica-Worms, D. Beyond the genome: molecular imaging in vivo with PET and SPECT. Acad Radiol 2001; 8:4-14. |
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Luker, G.D., Dahlheimer, J.L., Ostlund, R.E., Piwnica-Worms, D. Decreased hepatic accumulation and enhanced esterification of cholesterol in mice deficient in mdr1a and mdr1b P-glycoproteins. J Lipid Res 2001; 42:1389-1394. |
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Piwnica-Worms, D. Molecular imaging in the postgenomic era. Imaging Economics. CurAnt Communications, Inc., Los Angeles, 2001; 14:12-16. |
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Piwnica-Worms, D., Luker, K.E., Fracasso, P.M. Multidrug resistance, Part A: Breast cancer. In: Nuclear Oncology. Khalkhali, I., Maublant, J., Goldsmith, S.J. (editors), Lippincott Williams & Wilkins, Philadelphia, 2001; pp. 63-72. |
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Polyakov, V., Sharma, V., Dahlheimer, J.L., Pica, C.M., Luker, G.D., Piwnica-Worms, D. Novel Tat-peptide chelates for direct transduction of technetium-99m and rhenium into human cells for imaging and radiotherapy. Bioconjug Chem 2000; 11:762-771. |
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Tan, B., Piwnica-Worms, D., Ratner, L. Multidrug resistance transporters and modulation. Curr Opin Oncol 2000;12:450-458. |
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Luker, G.D., Pica, C.M., Kumar, A.S., Covey, D.F., Piwnica-Worms, D. Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains. Biochemistry 2000; 39:7651-7661. |
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